AMIGO1 Antibody (PACO37418)
- SKU:
- PACO37418
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AMIGO1 Antibody (PACO37418)
The AMIGO1 Polyclonal Antibody (PACO37418) is a valuable tool for researchers studying AMIGO1, a cell adhesion protein implicated in neuronal development and function. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the AMIGO1 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in neuroscience and neurodevelopmental disorders.AMIGO1, also known as Alivin 1, is known to play a crucial role in neuronal growth and guidance, as well as synaptic plasticity.
Its involvement in these processes makes it a compelling target for research related to neurological diseases and conditions such as Alzheimer's disease, schizophrenia, and autism spectrum disorders. Understanding the functions of AMIGO1 can provide valuable insights into the mechanisms underlying these disorders and may lead to the development of targeted therapies in the future.
| Antibody Name: | AMIGO1 Antibody (PACO37418) |
| Antibody SKU: | PACO37418 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Amphoterin-induced protein 1 protein (28-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO37418 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO37418 at dilution of 1:100. |
| Background: | Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
| Synonyms: | Amphoterin-induced protein 1 (AMIGO-1) (Alivin-2), AMIGO1, ALI2 AMIGO KIAA1163 |
| UniProt Protein Function: | AMIGO1: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Belongs to the immunoglobulin superfamily. AMIGO family.Protein type: Cell development/differentiation; Membrane protein, integralChromosomal Location of Human Ortholog: 1p13.3Cellular Component: axon; dendrite; perikaryon; voltage-gated potassium channel complexMolecular Function: potassium channel regulator activityBiological Process: axonal fasciculation; axonogenesis; heterophilic cell adhesion; homophilic cell adhesion; myelination; positive regulation of axonogenesis; positive regulation of synaptogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86WK6 |
| NCBI GenInfo Identifier: | 68052342 |
| NCBI Gene ID: | 57463 |
| NCBI Accession: | Q86WK6.1 |
| UniProt Secondary Accession: | Q86WK6,Q8IW71, Q9ULQ7, B4DIM3 |
| UniProt Related Accession: | Q86WK6 |
| Molecular Weight: | 55,239 Da |
| NCBI Full Name: | Amphoterin-induced protein 1 |
| NCBI Synonym Full Names: | adhesion molecule with Ig-like domain 1 |
| NCBI Official Symbol: | AMIGO1Â Â |
| NCBI Official Synonym Symbols: | ALI2; AMIGO; AMIGO-1Â Â |
| NCBI Protein Information: | amphoterin-induced protein 1 |
| UniProt Protein Name: | Amphoterin-induced protein 1 |
| UniProt Synonym Protein Names: | AMIGO-1; Alivin-2 |
| Protein Family: | |
| UniProt Gene Name: | AMIGO1Â Â |
| UniProt Entry Name: | AMGO1_HUMAN |
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