The ALY Rabbit Monoclonal Antibody (CAB4298) is a vital tool for researchers studying ALY, a protein involved in RNA metabolism and mRNA export. This antibody, produced using rabbit monoclonal technology, exhibits high specificity and sensitivity for ALY in human samples and is suitable for various applications including Western blot and immunohistochemistry.ALY, also known as THOC4, is a key player in the mRNA export pathway, playing a crucial role in the transport of mature mRNA from the nucleus to the cytoplasm. Dysregulation of ALY has been implicated in various human diseases, including cancer, making it a promising target for therapeutic interventions.
By utilizing the ALY Rabbit Monoclonal Antibody (CAB4298), researchers can gain insights into the function and regulation of ALY in cellular processes, paving the way for advancements in cancer research and drug development. Its high specificity and reactivity make it an essential tool for studying the intricate mechanisms underlying mRNA export and its implications in disease pathology.
Product Name:
THOC4/ALYREF Rabbit Monoclonal Antibody
SKU:
CAB4298
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 158-257 of human THOC4/ALYREFREF (Q86V81).
Nucleus. Nucleus speckle. Cytoplasm. Colocalizes with the core EJC, THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA.
Calculated MW:
27kDa
Observed MW:
32kDa
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.
Purification Method:
Affinity purification
Gene ID:
10189
Clone Number:
ARC0959
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using THOC4/THOC4/ALYREFREF Rabbit mAb (CAB4298) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
