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ALX4 Rabbit Polyclonal Antibody (CAB2834)

SKU:
CAB2834
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

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ALX4 Rabbit Polyclonal Antibody (CAB2834)

The ALX4 Polyclonal Antibody (CAB2834) is a powerful tool for researchers studying the ALX4 protein, a transcription factor involved in the development of various tissues and organs, including the skeleton and brain. This antibody is produced in rabbits and has been extensively validated for use in Western blot applications, providing accurate and reliable detection of ALX4 in human samples.ALX4 is a critical regulator of embryonic development and cell differentiation, making it a key player in processes such as bone formation and neural tube development.

Dysregulation of ALX4 has been linked to congenital disorders and certain types of cancer, highlighting its importance in human health and disease. By using the ALX4 Polyclonal Antibody, researchers can gain insight into the function and expression of ALX4 in different cell types and tissues, paving the way for advancements in developmental biology and disease research.

Product Name:ALX4 Rabbit Polyclonal Antibody
SKU:CAB2834
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ALX4 (NP_068745.2).
Sequence:MNAE TCVS YCES PAAA MDAY YSPV SQSR EGSS PFRA FPGG DKFG TTFL SAAA KAQG FGDA KSRA RYGA GQQD LATP LESG AGAR GSFN KFQP QPST PQPQ PPPQ PQPQ QQQP QPQP PAQP HLYL QRGA CKTP PDGS LKLQ EGSS GHSA ALQV PCYA KESS LGEP ELPP DSDT VGMD SSYL SVKE AGVK GPQD RASS DLPS PLEK ADSE SNKG KKRR NRTT
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:CRS5; FND2; ALX4
Positive Sample:HepG2
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:44kDa
Observed MW:44kDa

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.

Purification Method:Affinity purification
Gene ID:60529
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HepG2 cells, using ALX4 Rabbit pAb (CAB2834) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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