ALX3 Antibody (PACO62231)
- SKU:
- PACO62231
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ALX3 Antibody (PACO62231)
The ALX3 Polyclonal Antibody (PAC06231) is specifically designed for research involving ALX3, a transcription factor involved in the development of various tissues in the body. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ALX3 protein, this antibody enables researchers to detect and analyze ALX3 expression in different cell types, making it an ideal tool for investigations in developmental biology and regenerative medicine.
ALX3 is known for its essential role in embryonic development, particularly in the formation of the craniofacial region and other structures. Its involvement in tissue differentiation and organogenesis makes ALX3 a key target for studying developmental disorders and congenital abnormalities. Understanding the functions of ALX3 can provide insights into mechanisms underlying developmental processes and may lead to potential therapeutic strategies for treating developmental defects.
| Antibody Name: | ALX3 Antibody (PACO62231) |
| Antibody SKU: | PACO62231 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Homeobox protein aristaless-like 3 protein (11-127AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO62231 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Transcriptional regulator with a possible role in patterning of mesoderm during development. |
| Synonyms: | Homeobox protein aristaless-like 3 (Proline-rich transcription factor ALX3), ALX3 |
| UniProt Protein Function: | ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 1p13.3 Cellular Component: nucleus Molecular Function:sequence-specific DNA binding Biological Process: regulation of apoptosis; embryonic forelimb morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic hindlimb morphogenesis; pattern specification process; embryonic skeletal morphogenesis Disease: Frontonasal Dysplasia 1 |
| NCBI Summary: | This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95076 |
| NCBI GenInfo Identifier: | 113204604 |
| NCBI Gene ID: | 257 |
| NCBI Accession: | NP_006483.2 |
| UniProt Related Accession: | O95076 |
| Molecular Weight: | |
| NCBI Full Name: | homeobox protein aristaless-like 3 |
| NCBI Synonym Full Names: | ALX homeobox 3 |
| NCBI Official Symbol: | ALX3Â Â |
| NCBI Official Synonym Symbols: | FND; FND1Â Â |
| NCBI Protein Information: | homeobox protein aristaless-like 3 |
| UniProt Protein Name: | Homeobox protein aristaless-like 3 |
| UniProt Synonym Protein Names: | Proline-rich transcription factor ALX3 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | ALX3Â Â |
| UniProt Entry Name: | ALX3_HUMAN |
| Antibodies | ELISA Kits |
| ALX3 Antibody (PACO00390) | ALX3 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
ALX3 Antibody (PACO00390)
ALX3 Colorimetric Cell-Based ELISA
