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ALX3 Antibody (PACO00390)

SKU:
PACO00390
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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ALX3 Antibody (PACO00390)

The ALX3 Polyclonal Antibody (PACO00390) is a high-quality research tool designed for studying the ALX3 protein, a transcription factor crucial for developmental processes, specifically in embryonic development. The antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ALX3 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an ideal tool for investigations in developmental biology and regenerative medicine.

ALX3, also known as aristaless-like homeobox 3, plays a key role in regulating gene expression during embryonic development, particularly in the formation of craniofacial structures and neural crest cells. Its importance in controlling developmental processes makes it a valuable target for research into birth defects, craniofacial abnormalities, and disorders of the central nervous system. Understanding the function of ALX3 is essential for developing potential therapeutic strategies to address developmental disorders and promote tissue regeneration in clinical settings.

Antibody Name:ALX3 Antibody
Antibody SKU:PACO00390
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human ALX3.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ALX3; Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
UniProt Protein Function:ALX3: Transcriptional regulator with a possible role in patterning of mesoderm during development. Defects in ALX3 are the cause of frontonasal dysplasia type 1 (FND1); also called frontonasal malformation (FNM) or frontorhiny. The term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline. Belongs to the paired homeobox family.
UniProt Protein Details:

Protein type:DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: nucleus

Molecular Function:sequence-specific DNA binding

Biological Process: regulation of apoptosis; embryonic forelimb morphogenesis; transcription, DNA-dependent; regulation of transcription, DNA-dependent; embryonic hindlimb morphogenesis; pattern specification process; embryonic skeletal morphogenesis

Disease: Frontonasal Dysplasia 1

NCBI Summary:This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors. [provided by RefSeq, Jul 2008]
UniProt Code:O95076
NCBI GenInfo Identifier:113204604
NCBI Gene ID:257
NCBI Accession:NP_006483.2
UniProt Related Accession:O95076
Molecular Weight:
NCBI Full Name:homeobox protein aristaless-like 3
NCBI Synonym Full Names:ALX homeobox 3
NCBI Official Symbol:ALX3  
NCBI Official Synonym Symbols:FND; FND1  
NCBI Protein Information:homeobox protein aristaless-like 3
UniProt Protein Name:Homeobox protein aristaless-like 3
UniProt Synonym Protein Names:Proline-rich transcription factor ALX3
Protein Family:Homeobox protein
UniProt Gene Name:ALX3  
UniProt Entry Name:ALX3_HUMAN

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