ALS2 Rabbit Polyclonal Antibody (CAB7125)
- SKU:
- CAB7125
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | ALS2 Rabbit Polyclonal Antibody |
SKU: | CAB7125 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-429 of human ALS2 (NP_065970.2). |
Sequence: | GVTL TESQ AENH ASTA LSPS TETL DRQE EVFE NTLV ANDQ SVAT ELNA VSAQ ITSS DAMS SQQN VMGT TEIS SARN IPSY PDTQ AVNE YLRK LSDH SVRE DSEH GEKP VPSQ PLLE EAIP NLHS PPTT STSA LNSL VVSC ASAV GVRV AATY EAGA LSLK KVMN FYST TP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | ALSJ; PLSJ; IAHSP; ALS2CR6; ALS2 |
Positive Sample: | Jurkat,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | centrosome, cytoplasm, cytosol, dendrite, dendritic spine, early endosome, growth cone, nucleus, postsynaptic density |
Calculated MW: | 184kDa |
Observed MW: | 184kDa |
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 57679 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |