The ALSIN Polyclonal Antibody (CAB7125) is a valuable tool for research involving ALSIN, a protein associated with neurological disorders such as amyotrophic lateral sclerosis (ALS). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in immunohistochemistry and Western blot applications. By binding to the ALSIN protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in neurology and neurodegenerative diseases.
ALSLIN, also known as ALS2, is a key player in neuronal health and function, with mutations in the ALS2 gene linked to motor neuron degeneration in ALS patients. Understanding the role of ALSIN in neurodegeneration is crucial for developing potential therapies targeting this protein and addressing the underlying mechanisms of ALS and related disorders. By utilizing the ALSIN Polyclonal Antibody, researchers can gain valuable insights into the function of ALSIN and its implications for neurological health.
Product Name:
ALS2 Rabbit Polyclonal Antibody
SKU:
CAB7125
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 260-429 of human ALS2 (NP_065970.2).
centrosome, cytoplasm, cytosol, dendrite, dendritic spine, early endosome, growth cone, nucleus, postsynaptic density
Calculated MW:
184kDa
Observed MW:
184kDa
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
57679
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ALS2 antibody (CAB7125) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
