ALPP/ALPPL2 Antibody (PACO06876)
- SKU:
- PACO06876
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ALPP/ALPPL2 Antibody (PACO06876)
The ALPP/ALPPL2 Polyclonal Antibody (PACO06876) is a specialized research tool designed for the study of ALPP/ALPPL2, two closely related proteins known for their roles in bone development, mineralization, and phosphate metabolism. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it a valuable tool for Western blot applications.ALPP and ALPPL2 are alkaline phosphatases found in various tissues, including bone, liver, and kidney, where they play essential roles in regulating mineralization processes and maintaining phosphate homeostasis.
Research on these proteins is crucial for understanding their involvement in skeletal health, bone disorders, and mineral metabolism abnormalities.By targeting ALPP and ALPPL2, researchers can gain insights into the mechanisms underlying bone development, mineralization disorders, and phosphate-related pathologies. This antibody's ability to detect and analyze these proteins in different cell types makes it an excellent choice for studies focused on bone biology, metabolic diseases, and therapeutic interventions targeting ALPP and ALPPL2.
| Antibody Name: | ALPP/ALPPL2 Antibody (PACO06876) |
| Antibody SKU: | PACO06876 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human ALPP/ALPPL2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of customer's sample using ALPP/ALPPL2 Polyclonal Antibody. |
 | Western Blot analysis of 293 cells using ALPP/ALPPL2 Polyclonal Antibody. |
| Synonyms: | ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; ALPPL2; ALPPL; Alkaline phosphatase, placental-like |
| UniProt Protein Function: | ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Cofactor and Vitamin Metabolism - folate biosynthesis; Phosphatase (non-protein); Motility/polarity/chemotaxis; Membrane protein, GPI anchor; EC 3.1.3.1 Chromosomal Location of Human Ortholog: 2q37 Cellular Component: cell surface; plasma membrane; integral to membrane Molecular Function:zinc ion binding; alkaline phosphatase activity; magnesium ion binding Biological Process: dephosphorylation |
| NCBI Summary: | There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05187 |
| NCBI GenInfo Identifier: | 94721246 |
| NCBI Gene ID: | 250 |
| NCBI Accession: | NP_001623.3 |
| UniProt Secondary Accession: | P05187,P05188, P06861, Q53S78, Q96DB7, |
| UniProt Related Accession: | P05187 |
| Molecular Weight: | 57,954 Da |
| NCBI Full Name: | alkaline phosphatase, placental type preproprotein |
| NCBI Synonym Full Names: | alkaline phosphatase, placental |
| NCBI Official Symbol: | ALPPÂ Â |
| NCBI Official Synonym Symbols: | ALP; PALP; PLAP; PLAP-1Â Â |
| NCBI Protein Information: | alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme |
| UniProt Protein Name: | Alkaline phosphatase, placental type |
| UniProt Synonym Protein Names: | Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1 |
| Protein Family: | Phosphatase |
| UniProt Gene Name: | ALPPÂ Â |
| UniProt Entry Name: | PPB1_HUMAN |
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