The Alpha-Synuclein Polyclonal Antibody (CAB7215) is a valuable tool for researchers studying alpha-synuclein, a protein associated with neurodegenerative disorders such as Parkinson's disease. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding specifically to alpha-synuclein, researchers can detect and analyze this protein in various cell types, allowing for important insights into the pathology of neurodegenerative diseases.Alpha-synuclein is a key player in the formation of Lewy bodies, abnormal protein aggregates found in the brains of individuals with Parkinson's disease and other synucleinopathies.
By studying alpha-synuclein with this antibody, researchers can further unravel the mechanisms underlying these devastating disorders and potentially identify new therapeutic targets.Overall, the Alpha-Synuclein Polyclonal Antibody (CAB7215) is an essential tool for researchers interested in neurodegenerative diseases and the role of alpha-synuclein in their progression. Its specificity and reliability make it a valuable asset in the quest for effective treatments for these debilitating conditions.
Product Name:
α-Synuclein Rabbit Polyclonal Antibody
SKU:
CAB7215
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 59-140 of human alpha-Synuclein (NP_000336.1).
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
6622
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using α-Synuclein Rabbit pAb (CAB7215) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 1s.
