alpha + beta Synuclein Rabbit Monoclonal Antibody (CAB4899)
- SKU:
- CAB4899
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NACP
- PARK1
- PARK4
- PD1
Frequently bought together:
Description
Product Name: | alpha + beta Synuclein Rabbit Monoclonal Antibody |
SKU: | CAB4899 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human alpha + beta Synuclein (P37840). |
Sequence: | MDVF MKGL SKAK EGVV AAAE KTKQ GVAE AAGK TKEG VLYV GSKT KEGV VHGV ATVA EKTK EQVT NVGG AVVT GVTA VAQK TVEG AGSI AAAT GFVK KDQL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | NACP; PARK1; PARK4; PD1; alpha + beta Synuclein |
Positive Sample: | U-87MG,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, axon, axon terminus, cell cortex, cytoplasm, cytosol, extracellular region, extracellular space, growth cone, lysosome, mitochondrion, nucleus, perinuclear region of cytoplasm, plasma membrane, postsynapse, synaptic vesicle membrane |
Calculated MW: | 18kDa |
Observed MW: | 18kDa |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Purification Method: | Affinity purification |
Gene ID: | 6622/6620 |
Clone Number: | ARC1181 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |