The Alpha-Amanitin Proprotein Antibody (PACO34040) is a highly specific and sensitive tool for researchers studying the alpha-amanitin proprotein, a key player in RNA polymerase II inhibition. This polyclonal antibody, produced in rabbits, is optimized for use in Western blot and immunohistochemistry applications, allowing for the detection and analysis of the alpha-amanitin proprotein in various biological samples.The alpha-amanitin proprotein is a vital component in the mechanism of action of alpha-amanitin, a potent inhibitor of RNA polymerase II that has been widely used in research to study transcriptional regulation and gene expression.
By targeting the alpha-amanitin proprotein, researchers can gain valuable insights into the molecular pathways involved in RNA polymerase II inhibition and potentially identify novel therapeutic targets for diseases related to transcriptional dysregulation.With its high specificity and sensitivity, the Alpha-Amanitin Proprotein Antibody (PACO34040) is an essential tool for researchers interested in furthering our understanding of RNA polymerase II inhibition and its implications in various biological processes and disease states.
Antibody Name:
Alpha-amanitin proprotein Antibody (PACO34040)
Antibody SKU:
PACO34040
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Amanita phalloides
Immunogen:
Peptide sequence from Amanita phalloides Alpha-amanitin proprotein protein
Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters.
Function: Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters. Ref.1 Ref.2 Ref.3 Ref.4Toxic dose: LD50 is 0.35 mg/kg by intraperitoneal injection into mice. LD50 is 4 mg/kg by intravenous injection into rats, and 0.1 mg/kg by intravenous injection into dogs. LD50 is 2 µg/kg by intracerebroventricular injection into mice, and 10 µg/kg by intracerebroventricular injection into rats. Ref.3Caution: This peptide is cyclic. The peptide order is assigned by homology with the gene sequence for alpha-amanitin from Amanita bisporigera. Ref.4In peptide sequencing work prior to 1968, the residue shown in the first position was reported as a beta-methylleucine derivative that could arise by either beta-methylation of leucine or gamma-methylation of isoleucine. The correct structure has been determined to be derived from isoleucine without methylation. Ref.4
