ACTN2 Rabbit Polyclonal Antibody (CAB3718)
- SKU:
- CAB3718
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ACTN2 Rabbit Polyclonal Antibody |
SKU: | CAB3718 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ACTN2 (NP_001094.1). |
Sequence: | MNQI EPGV QYNY VYDE DEYM IQEE EWDR DLLL DPAW EKQQ RKTF TAWC NSHL RKAG TQIE NIEE DFRN GLKL MLLL EVIS GERL PKPD RGKM RFHK IANV NKAL DYIA SKGV KLVS IGAE EIVD GNVK MTLG MIWT IILR FAIQ DISV EETS AKEG LLLW CQRK TAPY RNVN IQNF HTSW KDGL GLCA LIHR HRPD LIDY SKLN KDDP IGNI NLAM EIAE KHLD IPKM LDAE DIVN TPKP DERA IMTY VS |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | MPD6; CMH23; CMYP8; CMD1AA; MYOCOZ; ACTN2 |
Positive Sample: | SH-SY5Y,HT-29,HeLa,Mouse heart,Mouse skeletal muscle,Mouse lung,Rat liver,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Z line, myofibril, sarcomere. |
Calculated MW: | 104kDa |
Observed MW: | 104kDa |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 88 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |