The Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody is a specialized research tool for studying the alpha-1 antitrypsin protein, a key inhibitor of proteases involved in tissue degradation. This antibody, generated in mice, exhibits high specificity and reactivity towards human samples, making it a reliable tool for Western blot and immunohistochemistry applications.Alpha-1 Antitrypsin, also known as AAT or SERPINA1, is an important serum protein that protects tissues from enzyme damage, particularly in the lungs and liver. Dysregulation of AAT has been implicated in various diseases such as emphysema, liver cirrhosis, and certain cancers, making it a valuable target for therapeutic interventions and diagnostic assays.
By using the Alpha-1 Antitrypsin (SERPINA1) Monoclonal Antibody, researchers can investigate the expression levels and localization of AAT in different cell types and tissues, providing crucial insights into its role in health and disease. This antibody is an essential tool for advancing our understanding of AAT biology and developing targeted treatments for related disorders.
The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5265
Clone Number:
ARC54184
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Confocal imaging of Hep G2 cells using Alpha-1 Antitrypsin (SERPINA1) Rabbit mAb (A21972,at dilution of 1:100) (Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.
