ALOXE3 Rabbit Polyclonal Antibody (CAB8245)
- SKU:
- CAB8245
- Product Type:
- Antibody
- Applications:
- WB
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | ALOXE3 Rabbit Polyclonal Antibody |
SKU: | CAB8245 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ALOXE3 (NP_067641.2). |
Sequence: | MAVY RLCV TTGP YLRA GTLD NISV TLVG TCGE SPKQ RLDR MGRD FAPG SVQK YKVR CTAE LGEL LLLR VHKE RYAF FRKD SWYC SRIC VTEP DGSV SHFP CYQW IEGY CTVE LRPG TART ICQD SLPL LLDH RTRE LRAR QECY RWKI YAPG FPCM VDVN SFQE MESD KKFA LTKT TTCV DQGD SSGN RYLP GFPM KIDI PSLM YMEP NVRY SATK TISL LFNA IPAS LGMK LRGL LDRK GSWK KLDD MQNI FWCH KTFT TKYV TEHW CEDH FFGY QYLN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | LI5; ARCI3; E-LOX; eLOX3; eLOX-3; ALOXE3 |
Positive Sample: | 22Rv1,MCF7,Mouse skeletal muscle,Mouse testis,Rat intestine |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 81kDa |
Observed MW: | 81kDa |
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 59344 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |