ALK Monoclonal Antibody (CAB22791)
- SKU:
- CAB22791
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | ALK Monoclonal Antibody |
SKU: | CAB22791 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence within amino acids 1334-1520 of human ALK (NP_004295.2). |
Sequence: | SNQE VLEF VTSG GRMD PPKN CPGP VYRI MTQC WQHQ PEDR PNFA IILE RIEY CTQD PDVI NTAL PIEY GPLV EEEE KVPV RPKD PEGV PPLL VSQQ AKRE EERS PAAP PPLP TTSS GKAA KKPT AAEI SVRV PRGP AVEG GHVN MAFS QSNP PSEL HKVH GSRN KPTS LWNP TYGS WFTE KPTK KNN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | ALK1; CD246; NBLST3; ALK |
Positive Sample: | SH-SY5Y,THP-1(Negative control) |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 176kDa |
Observed MW: | 140kDa/220kDa |
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
Purification Method: | Affinity purification |
Gene ID: | 238 |
Clone Number: | ARC58012 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |