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ALK Monoclonal Antibody (CAB22791)

SKU:
CAB22791
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

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ALK Monoclonal Antibody (CAB22791)

The ALK Monoclonal Antibody is a powerful tool for researchers studying the ALK protein, a key player in cancer development and progression. This antibody, derived from mouse cells, is highly specific and sensitive for detecting ALK in human samples, making it an essential tool for immunohistochemistry and immunofluorescence studies.ALK, also known as anaplastic lymphoma kinase, is a receptor tyrosine kinase that is frequently mutated or overexpressed in various cancers, particularly in lymphomas and non-small cell lung cancer. By targeting ALK with this antibody, researchers can gain valuable insights into the role of this protein in tumorigenesis and potentially identify new targets for therapy.

With its high specificity and reliability, the ALK Monoclonal Antibody is a valuable resource for cancer researchers looking to deepen their understanding of the molecular mechanisms driving cancer progression. Whether studying ALK signaling pathways or assessing ALK expression in tumor samples, this antibody is an essential tool for advancing cancer research and ultimately improving patient outcomes.

Product Name:ALK Monoclonal Antibody
SKU:CAB22791
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence within amino acids 1334-1520 of human ALK (NP_004295.2).
Sequence:SNQE VLEF VTSG GRMD PPKN CPGP VYRI MTQC WQHQ PEDR PNFA IILE RIEY CTQD PDVI NTAL PIEY GPLV EEEE KVPV RPKD PEGV PPLL VSQQ AKRE EERS PAAP PPLP TTSS GKAA KKPT AAEI SVRV PRGP AVEG GHVN MAFS QSNP PSEL HKVH GSRN KPTS LWNP TYGS WFTE KPTK KNN
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:ALK1; CD246; NBLST3; ALK
Positive Sample:SH-SY5Y,THP-1(Negative control)
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:176kDa
Observed MW:140kDa/220kDa

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).

Purification Method:Affinity purification
Gene ID:238
Clone Number:ARC58012
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using ALK Rabbit mAb (CAB22791) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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