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ALG6 Antibody (PACO07698)

SKU:
PACO07698
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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ALG6 Antibody (PACO07698)

The ALG6 Antibody (PACO7698) is a polyclonal antibody designed for research involving the ALG6 gene, which encodes for a key enzyme involved in the biosynthesis of asparagine-linked glycoproteins. The antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for a variety of research applications.ALG6 is essential for the proper functioning of the glycosylation pathway, which is crucial for the post-translational modification of proteins. Dysregulation of this pathway has been implicated in various diseases, including congenital disorders of glycosylation and cancer.

The ALG6 Antibody enables researchers to study the expression and localization of ALG6 in different cell types, providing valuable insight into its role in glycoprotein biosynthesis.By understanding the function of ALG6 and its involvement in glycosylation processes, researchers can uncover new therapeutic targets for diseases associated with glycosylation defects. The ALG6 Antibody is a valuable tool for advancing research in fields such as molecular biology, cell biology, and biochemistry.

Antibody Name:ALG6 Antibody (PACO07698)
Antibody SKU:PACO07698
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human ALG6
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:asparagine-linked glycosylation 6, α-1,3-glucosyltransferase homolog (S. cerevisiae);
UniProt Protein Function:ALG6: Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol. Defects in ALG6 are the cause of congenital disorder of glycosylation type 1C (CDG1C); also known as carbohydrate-deficient glycoprotein syndrome type V. CDGs are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1C patients have muscular hypotonia, show a delayed statomotor development and are mentally retarded. CDG1C is biochemically characterized by an accumulation of dolichyl pyrophosphate-linked Man(9)GlcNAc(2) in the endoplasmic reticulum. Belongs to the ALG6/ALG8 glucosyltransferase family.Protein type: Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; EC 2.4.1.267; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: 1p31.3Cellular Component: endoplasmic reticulum membrane; membraneMolecular Function: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity; glucosyltransferase activityBiological Process: dolichol-linked oligosaccharide biosynthetic process; oligosaccharide-lipid intermediate assembly; protein amino acid N-linked glycosylationDisease: Congenital Disorder Of Glycosylation, Type Ic
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type Ic. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y672
NCBI GenInfo Identifier:21263380
NCBI Gene ID:29929
NCBI Accession:Q9Y672.1
UniProt Secondary Accession:Q9Y672,Q5SXR9, Q9H3I0, B3KMU2
UniProt Related Accession:Q9Y672
Molecular Weight:58,181 Da
NCBI Full Name:Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
NCBI Synonym Full Names:ALG6, alpha-1,3-glucosyltransferase
NCBI Official Symbol:ALG6  
NCBI Official Synonym Symbols:CDG1C  
NCBI Protein Information:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProt Protein Name:Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProt Synonym Protein Names:Asparagine-linked glycosylation protein 6 homolog; Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase
Protein Family:Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProt Gene Name:ALG6  
UniProt Entry Name:ALG6_HUMAN

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