The ALG5 Polyclonal Antibody (CAB17693) is a valuable tool for research involving ALG5, an essential enzyme in the biosynthesis of asparagine-linked glycans. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the ALG5 protein, this antibody allows for the detection and analysis of ALG5 in various cell types, making it an ideal choice for studies in glycobiology and glycosylation research.ALG5 is a key player in the process of N-linked glycosylation, which is crucial for the proper folding and function of glycoproteins.
Dysregulation of N-linked glycosylation has been implicated in various diseases, including congenital disorders of glycosylation and cancer. By studying the role of ALG5 in glycosylation pathways, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic targets for intervention.Overall, the ALG5 Polyclonal Antibody (CAB17693) offers researchers a reliable tool for studying the function of ALG5 in glycosylation processes, opening up new avenues for research in the fields of glycobiology and disease biology.
Product Name:
ALG5 Rabbit Polyclonal Antibody
SKU:
CAB17693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 34-190 of human ALG5 (NP_037470.1).
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
29880
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALG5 Rabbit pAb (CAB17693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
