Anti-ALG13 Antibody (CAB18115)
- SKU:
- CAB18115
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-ALG13 Antibody (CAB18115)
The ALG13 Polyclonal Antibody (CAB18115) is a valuable tool for researchers studying ALG13, a vital enzyme involved in protein glycosylation and N-linked glycosylation pathways. This rabbit-derived antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By targeting the ALG13 protein, this antibody allows for accurate detection and analysis of ALG13 expression in various cell types, facilitating research in areas such as glycobiology, developmental biology, and disease mechanisms.ALG13 is essential for the proper glycosylation of proteins, a process critical for protein folding, stability, and function.
Dysregulation of protein glycosylation has been linked to a variety of diseases, including congenital disorders of glycosylation (CDG) and cancer. By understanding the role of ALG13 in these pathways, researchers can gain insight into potential therapeutic targets for treating these conditions.Overall, the ALG13 Polyclonal Antibody is a valuable tool for researchers investigating protein glycosylation and its implications in health and disease. Its high specificity and reactivity make it a reliable choice for studies aimed at furthering our understanding of glycosylation pathways and their role in various biological processes.
| Antibody Name: | Anti-ALG13 Antibody |
| Antibody SKU: | CAB18115 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ALG13. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, K-562, Jurkat, HepG2, Mouse liver, Mouse kidney |
| Immunogen: | Recombinant protein of human ALG13. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79868 |
| Uniprot: | Q9NP73 |
| Cellular Location: | |
| Calculated MW: | 18kDa/106kDa/117kDa/126kDa |
| Observed MW: | 126kDa |
 | Western blot - ALG13 Rabbit pAb (CAB18115) |
| Synonyms: | CDG1S, CXorf45, EIEE36, GLT28D1, MDS031, TDRD13, YGL047W, ALG13 |
| Background: | The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ALG13: Isoform 2 may be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway. Belongs to the glycosyltransferase 28 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Transferase; EC 2.4.1.141; Glycan Metabolism - N-glycan biosynthesis Chromosomal Location of Human Ortholog: Xq23 Cellular Component: endoplasmic reticulum membrane Molecular Function:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity Biological Process: dolichol-linked oligosaccharide biosynthetic process Disease: Congenital Disorder Of Glycosylation, Type Is |
| NCBI Summary: | The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q9NP73 |
| NCBI GenInfo Identifier: | 298286785 |
| NCBI Gene ID: | 79868 |
| NCBI Accession: | Q9NP73.2 |
| UniProt Secondary Accession: | Q9NP73,Q17RC3, Q5JXY9, B1AKD6, B1AKM1, B2R5L5, B7Z6J0 B7Z804, B7Z847, B7Z9A8, B7ZAJ1, B7ZB57, |
| UniProt Related Accession: | Q9NP73 |
| Molecular Weight: | 106,858 Da |
| NCBI Full Name: | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 |
| NCBI Synonym Full Names: | ALG13, UDP-N-acetylglucosaminyltransferase subunit |
| NCBI Official Symbol: | ALG13Â Â |
| NCBI Official Synonym Symbols: | CDG1S; EIEE36; MDS031; TDRD13; CXorf45; GLT28D1; YGL047WÂ Â |
| NCBI Protein Information: | putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 |
| UniProt Protein Name: | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 |
| UniProt Synonym Protein Names: | Asparagine-linked glycosylation 13 homolog; Glycosyltransferase 28 domain-containing protein 1; UDP-N-acetylglucosamine transferase subunit ALG13 homolog |
| Protein Family: | UDP-N-acetylglucosamine transferase |
| UniProt Gene Name: | ALG13Â Â |
| UniProt Entry Name: | ALG13_HUMAN |
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