The ALG12 Polyclonal Antibody (PAC015385) is a crucial tool for researchers studying ALG12, a gene involved in the glycosylation process. This antibody, derived from rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for Western blot applications. By targeting the ALG12 protein, this antibody enables precise detection and analysis in various cell types, facilitating research in the fields of glycobiology and genetic disorders.
ALG12 is a key player in the synthesis of dolichol-linked oligosaccharides, essential for proper protein glycosylation. Mutations in the ALG12 gene have been linked to various hereditary diseases, highlighting its importance in human health. By studying the function and regulation of ALG12, researchers can gain insights into the mechanisms underlying these disorders and potentially uncover new therapeutic targets for treatment.
Antibody Name:
ALG12 Antibody (PACO15385)
Antibody SKU:
PACO15385
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ALG12
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15385(ALG12 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lymphoma tissue using PACO15385(ALG12 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
Synonyms:
ALG12, alpha-1,6-mannosyltransferase
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]
