The Alg12 Polyclonal Antibody (PAC015384) is a valuable tool for research involving the Alg12 protein, a key enzyme involved in the process of N-linked glycosylation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to Alg12, it allows for the detection and analysis of this important protein in a variety of cell types.The Alg12 protein plays a crucial role in the glycosylation pathway, which is essential for the proper functioning of proteins in cells.
Dysregulation of N-linked glycosylation has been implicated in various diseases, including congenital disorders and cancer. Therefore, studying the function of Alg12 is vital for understanding these diseases and developing potential therapeutic interventions.With its high specificity and sensitivity, the Alg12 Polyclonal Antibody is a valuable asset for researchers in the fields of biochemistry, molecular biology, and disease pathology. Its applications in Western blot analysis make it an indispensable tool for studying the role of Alg12 in health and disease.
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: PC3 cells, Primary antibody: PACO15384(ALG12 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15384(ALG12 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation.
Synonyms:
ALG12, alpha-1,6-mannosyltransferase
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]
