null

ALG11 Antibody (PACO19093)

SKU:
PACO19093
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ALG11 Antibody PACO19093
  • ALG11 Antibody PACO19093
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

ALG11 Antibody (PACO19093)

The ALG11 Antibody (PAC01903) is a high-quality polyclonal antibody designed for research involving ALG11, a protein involved in the biosynthesis of N-linked glycoproteins. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in a variety of applications, including Western blot analysis. By binding specifically to the ALG11 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential tool for studies in glycobiology and protein glycosylation.ALG11 plays a crucial role in the process of N-linked glycosylation, which is essential for the proper folding and function of many secreted and membrane-bound proteins.

Dysregulation of this process has been implicated in a variety of diseases, including congenital disorders of glycosylation and certain types of cancer. Research into the function and regulation of ALG11 is therefore important for understanding the mechanisms underlying these conditions and potentially identifying new therapeutic targets. By using the ALG11 Antibody, researchers can further explore the role of ALG11 in protein glycosylation and its implications for human health.

Antibody Name:ALG11 Antibody (PACO19093)
Antibody SKU:PACO19093
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human ALG11
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19093(ALG11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO19093(ALG11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP).
Synonyms:ALG11, alpha-1,2-mannosyltransferase
UniProt Protein Function:ALG11: Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol- linked oligosaccharide chain. Defects in ALG11 are the cause of congenital disorder of glycosylation type 1P (CDG1P). A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.Protein type: EC 2.4.1.131; Transferase; Membrane protein, multi-pass; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integralChromosomal Location of Human Ortholog: 13q14.2Cellular Component: membraneDisease: Congenital Disorder Of Glycosylation, Type Ip
UniProt Protein Details:
NCBI Summary:This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
UniProt Code:Q2TAA5
NCBI GenInfo Identifier:156631015
NCBI Gene ID:440138
NCBI Accession:Q2TAA5.2
UniProt Secondary Accession:Q2TAA5,Q5TAN9, Q6DKI6, Q96FI7, A5PLP3, B4DKW9
UniProt Related Accession:Q2TAA5
Molecular Weight:55,651 Da
NCBI Full Name:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
NCBI Synonym Full Names:ALG11, alpha-1,2-mannosyltransferase
NCBI Official Symbol:ALG11  
NCBI Official Synonym Symbols:GT8; CDG1P  
NCBI Protein Information:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
UniProt Protein Name:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
UniProt Synonym Protein Names:Asparagine-linked glycosylation protein 11 homolog; Glycolipid 2-alpha-mannosyltransferase
Protein Family:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
UniProt Gene Name:ALG11  
UniProt Entry Name:ALG11_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products