Anti-ALDH8A1 Antibody (PACO15383)

Antibody Name:	ALDH8A1 Antibody (PACO15383)
Antibody SKU:	PACO15383
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ALDH8A1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15383(ALDH8A1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse liver tissue, Mouse kidney tissue, Primary antibody: PACO15383(ALDH8A1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15383(ALDH8A1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid, biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene.

Synonyms:

aldehyde dehydrogenase 8 family, member A1

UniProt Protein Function:	ALDH8A1: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). Belongs to the aldehyde dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 1.2.1.-; Oxidoreductase Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytoplasm; intracellular Molecular Function:aldehyde dehydrogenase (NAD) activity; retinal dehydrogenase activity Biological Process: retinal metabolic process; 9-cis-retinoic acid biosynthetic process; retinoic acid metabolic process
NCBI Summary:	This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:	Q9H2A2
NCBI GenInfo Identifier:	74752601
NCBI Gene ID:	64577
NCBI Accession:	Q9H2A2.1
UniProt Secondary Accession:	Q9H2A2,O60793, Q24JS9, Q53GT3, Q5TI80, B7Z521,
UniProt Related Accession:	Q9H2A2
Molecular Weight:	487
NCBI Full Name:	Aldehyde dehydrogenase family 8 member A1
NCBI Synonym Full Names:	aldehyde dehydrogenase 8 family, member A1
NCBI Official Symbol:	ALDH8A1
NCBI Official Synonym Symbols:	ALDH12; DJ352A20.2
NCBI Protein Information:	aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein
UniProt Protein Name:	Aldehyde dehydrogenase family 8 member A1
UniProt Synonym Protein Names:	Aldehyde dehydrogenase 12
Protein Family:	Aldehyde dehydrogenase family
UniProt Gene Name:	ALDH8A1
UniProt Entry Name:	AL8A1_HUMAN

Antibodies

ALDH8A1 Antibody (PACO07691)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)