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ALDH8A1 Antibody (PACO07691)

SKU:
PACO07691
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551
Frequently bought together:

Description

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ALDH8A1 Antibody (PACO07691)

The ALDH8A1 Polyclonal Antibody (PACO07691) is a valuable tool for research involving ALDH8A1, an enzyme involved in the metabolism of aldehydes and retinoids. The antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the ALDH8A1 protein, allowing for efficient detection and analysis in various cell types.ALDH8A1 plays a crucial role in cellular detoxification and the synthesis of retinoic acid, making it a key player in processes such as embryonic development and differentiation. Dysregulation of ALDH8A1 has been implicated in various diseases, including metabolic disorders and certain types of cancer.

Understanding the function of ALDH8A1 is important for elucidating its role in disease pathogenesis and identifying potential therapeutic targets.Researchers studying the metabolism of aldehydes and retinoids, as well as those investigating the role of ALDH8A1 in specific disease processes, will benefit from the use of the ALDH8A1 Polyclonal Antibody. Its high specificity and reactivity make it an ideal tool for advancing knowledge in the fields of biochemistry and molecular biology.

Antibody Name:ALDH8A1 Antibody (PACO07691)
Antibody SKU:PACO07691
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human ALDH8A1
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:aldehyde dehydrogenase 8 family, member A1;ALDH8A1;ALDH12;DJ352A20.2;DKFZp779D2315;MGC138650 ;
UniProt Protein Function:ALDH8A1: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro). Belongs to the aldehyde dehydrogenase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.2.1.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; intracellular

Molecular Function:aldehyde dehydrogenase (NAD) activity; retinal dehydrogenase activity

Biological Process: retinal metabolic process; 9-cis-retinoic acid biosynthetic process; retinoic acid metabolic process

NCBI Summary:This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:Q9H2A2
NCBI GenInfo Identifier:74752601
NCBI Gene ID:64577
NCBI Accession:Q9H2A2.1
UniProt Secondary Accession:Q9H2A2,O60793, Q24JS9, Q53GT3, Q5TI80, B7Z521,
UniProt Related Accession:Q9H2A2
Molecular Weight:487
NCBI Full Name:Aldehyde dehydrogenase family 8 member A1
NCBI Synonym Full Names:aldehyde dehydrogenase 8 family, member A1
NCBI Official Symbol:ALDH8A1  
NCBI Official Synonym Symbols:ALDH12; DJ352A20.2  
NCBI Protein Information:aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase 12; aldehyde dehydrogenase family protein
UniProt Protein Name:Aldehyde dehydrogenase family 8 member A1
UniProt Synonym Protein Names:Aldehyde dehydrogenase 12
Protein Family:Aldehyde dehydrogenase family
UniProt Gene Name:ALDH8A1  
UniProt Entry Name:AL8A1_HUMAN

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