The ALDH6A1 Polyclonal Antibody (CAB14750) is a valuable tool for researchers studying ALDH6A1, an enzyme involved in the metabolism of amino acids and nitrogen-containing compounds. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ALDH6A1 protein, this antibody allows for accurate detection and analysis in various cell types, making it ideal for investigations in biochemistry and metabolism research.ALDH6A1, a member of the aldehyde dehydrogenase family, plays a crucial role in the breakdown of amino acids and other nitrogen-containing molecules.
Dysregulation of ALDH6A1 has been linked to metabolic disorders and genetic diseases, making it a promising target for therapeutic interventions. By studying the function and expression of ALDH6A1, researchers can gain insights into its potential role in diseases such as hyperammonemia and Maple Syrup Urine Disease, paving the way for the development of novel treatment strategies.
Product Name:
ALDH6A1 Rabbit Polyclonal Antibody
SKU:
CAB14750
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 326-535 of human ALDH6A1 (NP_005580.1).
This gene encodes a member of the aldehyde dehydrogenase protein family. The encoded protein is a mitochondrial methylmalonate semialdehyde dehydrogenase that plays a role in the valine and pyrimidine catabolic pathways. This protein catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4329
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat ovary using ALDH6A1 Rabbit pAb (CAB14750) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
