The ALDH5A1 Polyclonal Antibody (CAB16074) is specifically designed for research involving ALDH5A1, an enzyme involved in the metabolism of acetaldehyde and various aliphatic aldehydes. The antibody, raised in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the ALDH5A1 protein, this antibody enables the detection and analysis of ALDH5A1 in a variety of cell types, making it an excellent tool for studying metabolic pathways and potentially contributing to the development of treatments for conditions related to aldehyde metabolism dysfunction.
ALDH5A1, also known as succinate-semialdehyde dehydrogenase, plays a crucial role in detoxifying aldehydes, which are toxic byproducts of various biochemical reactions. Dysregulation of ALDH5A1 activity is associated with metabolic disorders and neurological conditions, making it a promising target for therapeutic intervention. Research into the function of ALDH5A1 is essential for advancing our understanding of these diseases and developing targeted therapies to address them.
Product Name:
ALDH5A1 Rabbit Polyclonal Antibody
SKU:
CAB16074
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ALDH5A1 (NP_001071.1).
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
7915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse liver, using ALDH5A1 Rabbit pAb (CAB16074) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
