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ALDH5A1 Monoclonal Antibody [PAT17F5AT] (CPAB0223)

SKU:
CPAB0223
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT17F5AT
Applications:
ELISA
FC
€149
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Description

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ALDH5A1 Monoclonal Antibody [PAT17F5AT] (CPAB0223)

The ALDH5A1 Polyclonal Antibody (CPAB0223) is a valuable tool for researchers studying ALDH5A1, a crucial enzyme involved in the metabolism of various compounds, particularly within the brain and liver. This antibody, raised in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications.ALDH5A1 plays a key role in the breakdown of toxic compounds such as succinate semialdehyde, a byproduct of the GABA neurotransmitter pathway. Mutations in the ALDH5A1 gene have been linked to disorders such as succinic semialdehyde dehydrogenase deficiency, which can lead to neurological symptoms and cognitive impairment.

By targeting the ALDH5A1 protein, researchers can better understand its function in normal physiological processes and its impact on disease pathology. This antibody enables the detection and analysis of ALDH5A1 in various cell types, making it an essential tool for studies in neurobiology, metabolism, and enzyme regulation.Overall, the ALDH5A1 Polyclonal Antibody is a valuable resource for researchers investigating the role of ALDH5A1 in health and disease, providing insights that may lead to the development of new therapeutic approaches for metabolic disorders and neurological conditions.

Product Name:ALDH5A1 Antibody
Product Sku:CPAB0223
Size:5μg
Host Species:Mouse
Immunogen:Anti-human ALDH5A1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human ALDH5A1 protein 48-535 amino acids purified from Ecoli.
Clone:PAT17F5AT.
Reactivity:Human
Applications:ELISA, Flow Cytometry
Purification Method:ALDH5A1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:ALDH5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase, which is a member of the aldehyde dehydrogenase family of proteins. The ALDH5A1 protein functions as a mediator to the NADP+-dependent oxidation of aldehydes into acids and has an imperative role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH5A1 is expressed in various tissues, including the liver, heart, lung, brain, kidney and placenta. Deficiency in the ALDH5A1 enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to this defect, physiologic fluids from patients accumulate GHB, which is a compound with numerous neuromodulatory properties.
Synonyms:Succinate-semialdehyde dehydrogenase mitochondrial, Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, ALDH5A1, SSADH, SSDH.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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