The ALDH4A1 Polyclonal Antibody (CAB13569) is a valuable tool for researchers studying ALDH4A1, an enzyme involved in the degradation of amino acids. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. By binding to the ALDH4A1 protein, this antibody enables researchers to detect and analyze the enzyme in various cell types, making it an excellent choice for studies in biochemistry and metabolism research.
ALDH4A1, also known as delta-1-piperideine-6-carboxylate dehydrogenase, plays a crucial role in the catabolism of proline and hydroxyproline, key amino acids in collagen synthesis. Dysregulation of ALDH4A1 has been implicated in various diseases, including collagen disorders and neurological conditions. Further research into the function and regulation of ALDH4A1 could provide valuable insights into these disease mechanisms and potential therapeutic targets.
Product Name:
ALDH4A1 Rabbit Polyclonal Antibody
SKU:
CAB13569
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 354-563 of human ALDH4A1 (NP_003739.2).
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
8659
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ALDH4A1 antibody (CAB13569) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
