The ALDH3A1 Polyclonal Antibody (CAB5502) is a valuable tool for researchers studying ALDH3A1, a member of the aldehyde dehydrogenase family known for its role in detoxifying reactive aldehydes. Produced in rabbits, this antibody is highly specific to human ALDH3A1 and has been validated for Western blot applications. By binding to the ALDH3A1 protein, this antibody enables the detection and analysis of ALDH3A1 in various cell types, making it ideal for studies in biology, biochemistry, and toxicology.ALDH3A1 is highly expressed in tissues that are exposed to environmental toxins, such as the liver and lung, where it plays a crucial role in protecting cells from oxidative stress.
Its ability to detoxify harmful aldehydes makes it a potential target for research on diseases related to oxidative damage, such as cancer, cardiovascular diseases, and neurodegenerative disorders. By understanding the function of ALDH3A1, researchers can develop novel strategies to enhance cellular protection and combat oxidative damage.
Product Name:
ALDH3A1 Rabbit Polyclonal Antibody
SKU:
CAB5502
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ALDH3A1 (NP_001128640.1).
Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
218
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of A-549 cells, using ALDH3A1 antibody (CAB5502) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
