The ALDH2 Polyclonal Antibody (CAB1226) is a valuable tool for researchers studying ALDH2, an enzyme involved in alcohol metabolism and the detoxification of aldehydes. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot applications. By binding to the ALDH2 protein, this antibody facilitates the detection and analysis of ALDH2 in a variety of cell types, making it ideal for research in toxicology, pharmacology, and alcohol-related studies.ALDH2 plays a crucial role in protecting cells from oxidative stress and DNA damage by metabolizing toxic aldehydes generated during alcohol metabolism.
Research into the function and regulation of ALDH2 is essential for understanding the mechanisms of alcohol-related diseases, such as alcoholic liver disease and alcohol-induced cancers. Additionally, ALDH2 polymorphisms have been linked to increased susceptibility to these conditions, making it a potential target for therapeutic interventions.Overall, the ALDH2 Polyclonal Antibody (CAB1226) is a valuable tool for researchers investigating the role of ALDH2 in alcohol metabolism, oxidative stress, and alcohol-related diseases. Its specificity and sensitivity make it a reliable choice for studies in pharmacology, toxicology, and molecular biology.
Product Name:
ALDH2 Rabbit Polyclonal Antibody
SKU:
CAB1226
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 321-480 of human ALDH2 (NP_000681.2).
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
217
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALDH2 Rabbit pAb (CAB1226) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
