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ALDH2 Monoclonal Antibody [PAT2C10AT] (CPAB0252)

SKU:
CPAB0252
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT2C10AT
Applications:
WB
ELISA
$179
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Description

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ALDH2 Monoclonal Antibody [PAT2C10AT] (CPAB0252)

The ALDH2 Polyclonal Antibody (CPAB0252) is a valuable tool for researchers studying ALDH2, a key enzyme involved in alcohol metabolism and oxidative stress response. This antibody, produced in rabbits, is highly specific for detecting ALDH2 in human samples and is validated for use in Western blot applications. By binding to the ALDH2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an excellent choice for studies in pharmacology, toxicology, and alcohol-related research.ALDH2, also known as aldehyde dehydrogenase 2, plays a crucial role in detoxifying acetaldehyde, a toxic byproduct of alcohol metabolism.

Deficiencies in ALDH2 have been linked to an increased risk of alcohol-related health issues, making it a compelling target for studies on alcoholism, liver diseases, and cardiovascular disorders. Investigating the function of ALDH2 can provide valuable insights into understanding and potentially treating these conditions, highlighting the significance of this antibody in advancing biomedical research.

Product Name:ALDH2 Antibody
Product Sku:CPAB0252
Size:5μg
Host Species:Mouse
Immunogen:Anti-human ALDH2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ALDH2 amino acids 18-517 purified from Ecoli.
Clone:PAT2C10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:ALDH2 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:ALDH2 is part of the aldehyde dehydrogenase family of proteins which catalyze the chemical transformation from acetaldehyde to acetic acid. ALDH2 is the second enzyme of the major oxidative pathway of alcohol metabolism. ALDH2 has 2 major liver isoforms: cytosolic and mitochondrial, which differ by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Nearly all Caucasians have 2 major isozymes, whereas roughly 50% of Orientals have only the cytosolic isozyme, omitting the mitochondrial isozyme. The extremely higher rate of acute alcohol intoxication with Orientals compared to Caucasians is due to the fact of the absence of mitochondrial isozyme. ALDH2 has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms:ALDM, ALDHI, ALDH-E2, MGC1806, ALDH2, Aldehyde dehydrogenase mitochondrial, ALDH class 2.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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