The ALDH1L2 Polyclonal Antibody (CAB14455) is an essential tool for researchers studying ALDH1L2, an enzyme involved in folate metabolism and cancer development. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By binding to ALDH1L2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it a valuable asset in the fields of oncology and metabolic research.ALDH1L2, a member of the aldehyde dehydrogenase family, plays a crucial role in maintaining cellular folate levels and DNA synthesis.
Dysregulation of ALDH1L2 has been implicated in various types of cancer, highlighting its potential as a therapeutic target. By elucidating the function and regulation of ALDH1L2, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially identify novel strategies for cancer treatment.Overall, the ALDH1L2 Polyclonal Antibody (CAB14455) offers researchers a reliable tool for investigating the role of ALDH1L2 in cancer biology and metabolic pathways, paving the way for the development of targeted therapies and diagnostic tools in the fight against cancer.
Product Name:
ALDH1L2 Rabbit Polyclonal Antibody
SKU:
CAB14455
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-480 of human ALDH1L2 (NP_001029345.2).
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
160428
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALDH1L2 Rabbit pAb (CAB14455) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
