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Anti-ALDH1L1 Antibody (CAB7707)

SKU:
CAB7707
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-ALDH1L1 Antibody
Antibody SKU:CAB7707
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ALDH1L1
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Rat liver
Immunogen:A synthesized peptide derived from human ALDH1L1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10840
Uniprot:O75891
Cellular Location:
Calculated MW:99kDa
Observed MW:100KDa
Synonyms:10-FTHFDH, 10-fTHF, FDH, FTHFD
Background:The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
UniProt Protein Function:ALDH1L1: 2 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Cofactor and Vitamin Metabolism - one carbon pool by folate; Oxidoreductase; EC 1.5.1.6

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: mitochondrion

Molecular Function:methyltransferase activity; aldehyde dehydrogenase (NAD) activity; formyltetrahydrofolate dehydrogenase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity

Biological Process: methylation; biosynthetic process; one-carbon compound metabolic process; 10-formyltetrahydrofolate catabolic process

NCBI Summary:The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
UniProt Code:O75891
NCBI GenInfo Identifier:59802911
NCBI Gene ID:10840
NCBI Accession:O75891.2
UniProt Secondary Accession:O75891,Q68CS1, B4DG36, E9PBX3,
UniProt Related Accession:O75891
Molecular Weight:902
NCBI Full Name:Cytosolic 10-formyltetrahydrofolate dehydrogenase
NCBI Synonym Full Names:aldehyde dehydrogenase 1 family, member L1
NCBI Official Symbol:ALDH1L1  
NCBI Official Synonym Symbols:FDH; FTHFD; 10-fTHF; 10-FTHFDH  
NCBI Protein Information:cytosolic 10-formyltetrahydrofolate dehydrogenase; MER57B-ALDH1L1
UniProt Protein Name:Cytosolic 10-formyltetrahydrofolate dehydrogenase
UniProt Synonym Protein Names:Aldehyde dehydrogenase family 1 member L1
Protein Family:Cytosolic 10-formyltetrahydrofolate dehydrogenase
UniProt Gene Name:ALDH1L1  
UniProt Entry Name:AL1L1_HUMAN
Anti-ALDH1L1 Antibody (CAB7707)Western blot - ALDH1L1 Rabbit mAb (CAB7707)

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