The ALDH1L1 Polyclonal Antibody (CAB7067) is a vital tool for researchers studying ALDH1L1, an enzyme involved in the folate metabolic pathway and associated with cancer and neurodegenerative diseases. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ALDH1L1 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in cancer biology and neuroscience.ALDH1L1, also known as mitochondrial 10-formyltetrahydrofolate dehydrogenase, plays a crucial role in maintaining cellular folate levels and nucleotide synthesis, making it a potential target for cancer therapy.
Additionally, ALDH1L1 has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's, highlighting its importance in brain function and development. Understanding the function of ALDH1L1 is essential for uncovering its role in disease pathogenesis and identifying potential therapeutic interventions.
Product Name:
ALDH1L1 Rabbit Polyclonal Antibody
SKU:
CAB7067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALDH1L1 (NP_036322.2).
The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, nicotinamide adenine dinucleotide phosphate (NADP+), and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family. Loss of function or expression of this gene is associated with decreased apoptosis, increased cell motility, and cancer progression. There is an antisense transcript that overlaps on the opposite strand with this gene locus. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10840
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALDH1L1 Rabbit pAb (CAB7067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
