The ALDH1A3 Polyclonal Antibody (CAB15230) is a valuable tool for researchers studying ALDH1A3, an enzyme involved in the metabolism of retinoic acid and potentially implicated in cancer progression. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ALDH1A3 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential reagent for studies in oncology and cell biology.
ALDH1A3 is known for its role in retinoic acid metabolism and has been linked to cancer development and progression. Studies have shown that ALDH1A3 may contribute to drug resistance and stem cell-like properties in cancer cells, making it an attractive target for therapeutic interventions. By investigating the function and regulation of ALDH1A3, researchers can gain valuable insights into cancer biology and potentially identify new treatment strategies for patients with aggressive or treatment-refractory tumors.
Product Name:
ALDH1A3 Rabbit Polyclonal Antibody
SKU:
CAB15230
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human ALDH1A3 (NP_000684.2).
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
220
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using ALDH1A3 Rabbit pAb (CAB15230) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
