The ALDH1A2 Polyclonal Antibody (CAB7503) is a valuable tool for researching ALDH1A2, an enzyme involved in the synthesis of retinoic acid and cellular differentiation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ALDH1A2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in developmental biology, stem cell research, and cancer biology.
ALDH1A2 is a key player in the retinoic acid signaling pathway, which regulates gene expression and cell growth. Dysregulation of this pathway has been implicated in various diseases, including cancer, developmental disorders, and metabolic conditions. The ability to accurately detect and study ALDH1A2 levels in different cell types is crucial for understanding its role in health and disease, and for developing targeted therapies that leverage its functions.
Product Name:
ALDH1A2 Rabbit Polyclonal Antibody
SKU:
CAB7503
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human ALDH1A2 (NP_733797.1).
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
8854
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALDH1A2 Rabbit pAb (CAB7503) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
