ALDH18A1 Rabbit Polyclonal Antibody (CAB12247)
- SKU:
- CAB12247
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | ALDH18A1 Rabbit Polyclonal Antibody |
SKU: | CAB12247 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2). |
Sequence: | MLSQ VYRC GFQP FNQH LLPW VKCT TVFR SHCI QPSV IRHV RSWS NIPF ITVP LSRT HGKS FAHR SELK HAKR IVVK LGSA VVTR GDEC GLAL GRLA SIVE QVSV LQNQ GREM MLVT SGAV AFGK QRLR HEIL LSQS VRQA LHSG QNQL KEMA IPVL EARA CAAA GQSG LMAL YEAM FTQY SICA AQIL VTNL DFHD EQKR RNLN GTLH ELLR MNIV PIVN TNDA VVPP AEPN SDLQ GVNV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GSAS; P5CS; PYCS; SPG9; ADCL3; SPG9A; SPG9B; ARCL3A; ALDH18A1 |
Positive Sample: | U-87MG,Mouse testis,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion inner membrane. |
Calculated MW: | 87kDa |
Observed MW: | 87kDa |
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5832 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |