The ALDH18A1 Polyclonal Antibody (CAB12247) is a valuable tool for research involving ALDH18A1, a protein associated with the synthesis of proline, a crucial amino acid involved in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ALDH18A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for studies in biochemistry and molecular biology.ALDH18A1, also known as pyrroline-5-carboxylate synthase, plays a key role in proline biosynthesis, which is essential for cellular function and stress response. Dysregulation of proline metabolism has been implicated in various diseases, including cancer, neurodegenerative disorders, and connective tissue diseases.
Understanding the function of ALDH18A1 is vital for unraveling the mechanisms underlying these conditions and developing potential therapeutic strategies targeting proline metabolism.Overall, the ALDH18A1 Polyclonal Antibody (CAB12247) is a valuable asset for researchers exploring the intricate pathways involving proline biosynthesis and its implications in health and disease. Its high specificity and sensitivity make it a reliable tool for elucidating the role of ALDH18A1 in various cellular processes, paving the way for advancements in biomedical research.
Product Name:
ALDH18A1 Rabbit Polyclonal Antibody
SKU:
CAB12247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ALDH18A1 (NP_002851.2).
This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
5832
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ALDH18A1 Rabbit pAb (CAB12247) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
