The ALB Polyclonal Antibody (PAC063935) is specifically designed for research involving the ALB protein, also known as albumin, a crucial serum protein with various functions in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ALB protein, this antibody allows for the detection and analysis of albumin in different cell types, making it an excellent tool for studies in biology, medicine, and biochemistry.Albumin is the most abundant protein in human blood plasma and plays essential roles in maintaining osmotic pressure, transporting hormones and drugs, and regulating pH levels.
Its involvement in numerous physiological processes highlights its importance in health and disease, making it a valuable target for research in fields such as nephrology, hepatology, and molecular biology. The ALB Polyclonal Antibody provides a reliable tool for investigating the functions and mechanisms of albumin in various biological contexts, ultimately contributing to the advancement of scientific understanding and potential therapeutic developments.
Western Blot. Positive WB detected in: Rat heart tissue, Rat liver tissue, Rat spleen tissue, Rat brain tissue. All lanes: Alb antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 69 kDa. Observed band size: 69 kDa.
Background:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acid, , hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Synonyms:
Serum albumin, Alb
UniProt Protein Function:
albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Carrier; Secreted; Secreted, signal peptide
Molecular Function:toxin binding; enzyme binding; DNA binding; zinc ion binding; chaperone binding; drug binding; oxygen binding; fatty acid binding; pyridoxal phosphate binding
Biological Process: response to organic substance; response to mercury ion; retinal homeostasis; transport; maintenance of mitochondrion localization; hemolysis by symbiont of host red blood cells; cellular response to starvation; vasodilation; positive regulation of circadian sleep/wake cycle, non-REM sleep; response to nutrient; negative regulation of apoptosis
NCBI Summary:
may play a role in nitric oxide signaling; may mediate formation of S-nitrosothiols [RGD, Feb 2006]
