AKTIP Rabbit Polyclonal Antibody (CAB6239)
- SKU:
- CAB6239
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | AKTIP Rabbit Polyclonal Antibody |
SKU: | CAB6239 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human AKTIP (NP_071921.1). |
Sequence: | MNPF WSMS TSSV RKRS EGEE KTLT GDVK TSPP RTAP KKQL PSIP KNAL PITK PTSP APAA QSTN GTHA SYGP FYLE YSLL AEFT LVVK QKLP GVYV QPSY RSAL MWFG VIFI RHGL YQDG VFKF TVYI PDNY PDGD CPRL VFDI PVFH PLVD PTSG ELDV KRAF AKWR RNHN HIWQ VLMY ARRV FYKI DTAS PLNP EAAV LYEK DIQL FKSK VVDS VKVC TARL FDQP KIED PYAI SFSP WNPS VHDE AREK MLTQ KKPE EQHN KSVH VAGL SWVK PGSV QPFS KEEK TVAT |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | FT1; FTS; AKTIP |
Positive Sample: | HepG2,MCF7,293T,Mouse brain,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Peripheral membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 36kDa |
The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.
Purification Method: | Affinity purification |
Gene ID: | 64400 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |