AKR1C3 Rabbit Polyclonal Antibody (CAB13568)
- SKU:
- CAB13568
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | AKR1C3 Rabbit Polyclonal Antibody |
SKU: | CAB13568 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_003730.4). |
Sequence: | MDSK HQCV KLND GHFM PVLG FGTY APPE VPRS KALE VTKL AIEA GFRH IDSA HLYN NEEQ VGLA IRSK IADG SVKR EDIF YTSK LWST FHRP ELVR PALE NSLK KAQL DYVD LYLI HSPM SLKP GEEL SPTD ENGK VIFD IVDL CTTW EAME KCKD AGLA KSIG VSNF NRRQ LEMI LNKP GLKY KPVC NQVE CHPY FNRS KLLD FCKS KDIV LVAY SALG SQRD KRWV DPNS PVLL EDPV LCAL AKKH KRTP ALIA LRYQ LQRG VVVL AKSY NEQR IRQN VQVF EFQL TAED MKAI DGLD RNLH YFNS DSFA SHPN YPYS DEY |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS; AKR1C3 |
Positive Sample: | HeLa,HepG2,A-549,THP-1(low expression control) |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 37kDa |
Observed MW: | 37kDa |
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8644 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |