The AKR1C3 Polyclonal Antibody (CAB13568) is a valuable tool for research involving the AKR1C3 protein, a member of the aldo-keto reductase superfamily. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the AKR1C3 protein, this antibody enables researchers to detect and analyze AKR1C3 expression in various cell types, making it a valuable asset for studies in cancer research and drug development.AKR1C3, also known as 17-beta-hydroxysteroid dehydrogenase, plays a critical role in the metabolism of androgens and estrogen, making it a potential target for therapeutic interventions in hormone-dependent cancers such as prostate and breast cancer.
Understanding the function and regulation of AKR1C3 is essential for the development of novel treatments that target this enzyme in cancer therapy. The AKR1C3 Polyclonal Antibody provides researchers with a reliable tool to explore the role of AKR1C3 in cancer biology and drug resistance mechanisms.
Product Name:
AKR1C3 Rabbit Polyclonal Antibody
SKU:
CAB13568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_003730.4).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8644
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using AKR1C3 Rabbit pAb (CAB13568) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
