The AKR1C2 Polyclonal Antibody (CAB1048) is a valuable tool for researchers studying AKR1C2, an enzyme involved in steroid metabolism and prostaglandin synthesis. The antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting AKR1C2 protein in human samples. Validated for use in Western blotting applications, it allows for accurate analysis of AKR1C2 expression in various cell types.AKR1C2, a member of the aldo-keto reductase family, plays a crucial role in the metabolism of endogenous and exogenous compounds, making it a key target for research in cancer biology, endocrinology, and drug metabolism studies.
Understanding the function and regulation of AKR1C2 is essential for developing therapeutic strategies for cancer treatment and hormone-related disorders.Overall, the AKR1C2 Polyclonal Antibody (CAB1048) is a valuable tool for scientists looking to explore the roles of AKR1C2 in health and disease, providing insights into its potential as a therapeutic target in various medical conditions.
Product Name:
AKR1C2 Rabbit Polyclonal Antibody
SKU:
CAB1048
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C2 (NP_995317.1).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1646
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using AKR1C2 Rabbit pAb (CAB1048) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
