The AKR1C1 Polyclonal Antibody (CAB13004) is a vital tool for researchers studying AKR1C1, an enzyme involved in steroid metabolism and inflammation regulation. This polyclonal antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various applications including Western blot analysis.AKR1C1, also known as aldo-keto reductase family 1 member C1, plays a crucial role in the biosynthesis of steroid hormones and prostaglandins, making it a promising target for research in fields such as endocrinology, oncology, and inflammation.
Its dysregulation has been implicated in various diseases including cancers and inflammatory disorders, highlighting the importance of studying its expression and activity.By utilizing the AKR1C1 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of AKR1C1 in different cell types and disease states. This antibody enables the detection and analysis of AKR1C1 protein levels, facilitating a better understanding of its role in physiological processes and disease pathogenesis.
Product Name:
AKR1C1 Rabbit Polyclonal Antibody
SKU:
CAB13004
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C1 (NP_001344.2).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Purification Method:
Affinity purification
Gene ID:
1645
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using AKR1C1 Rabbit pAb (CAB13004) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
