The AKR1B10 Polyclonal Antibody (CAB7823) is a valuable tool for researchers studying AKR1B10, an enzyme overexpressed in various cancers and implicated in tumor progression. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the AKR1B10 protein, this antibody allows for detection and analysis in a variety of cell types, making it ideal for investigations in cancer biology and drug development.AKR1B10, also known as aldose reductase family 1 member B, is involved in cellular detoxification processes and plays a role in metabolizing lipid peroxidation products.
Its overexpression has been linked to drug resistance and poor prognosis in cancer patients, making it a potential therapeutic target for cancer treatment. Research on AKR1B10 is essential for understanding its role in cancer development and identifying novel strategies for combating drug resistance and improving patient outcomes in oncology.
Product Name:
AKR1B10 Rabbit Polyclonal Antibody
SKU:
CAB7823
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B10 (NP_064695.3).
293T,Mouse small intestine,Mouse stomach,Mouse liver,Mouse kidney,Rat small intestine
Conjugate:
Unconjugated
Cellular Localization:
Lysosome, Secreted.
Calculated MW:
36kDa
Observed MW:
36kDa
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis.
Purification Method:
Affinity purification
Gene ID:
57016
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using AKR1B10 Rabbit pAb (CAB7823) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
