The AKR1B1 Polyclonal Antibody (CAB13944) is a valuable tool for researchers studying AKR1B1, an important enzyme involved in the metabolism of glucose and lipid aldehydes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the AKR1B1 protein, this antibody allows for the detection and analysis of AKR1B1 expression in various cell types, making it an ideal choice for studies in metabolic diseases and cancer research.AKR1B1, also known as aldose reductase, plays a crucial role in cellular detoxification processes by reducing toxic aldehydes to their corresponding alcohols.
Dysregulation of AKR1B1 activity has been implicated in the development of diabetic complications, as well as certain types of cancers. Therefore, further research into the function of AKR1B1 is essential for the development of targeted therapies for these conditions. Overall, the AKR1B1 Polyclonal Antibody (CAB13944) serves as a valuable tool for researchers aiming to elucidate the role of AKR1B1 in various physiological and pathological processes, opening up new avenues for therapeutic interventions in metabolic disorders and cancer.
Product Name:
AKR1B1 Rabbit Polyclonal Antibody
SKU:
CAB13944
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-316 of human AKR1B1 (NP_001619.1).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database.
Purification Method:
Affinity purification
Gene ID:
231
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AKR1B1 antibody (CAB13944) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
