The AKR1A1 Polyclonal Antibody (CAB1068) is a vital tool for researchers studying AKR1A1, a key enzyme involved in cellular detoxification and antioxidant defense mechanisms. This antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting AKR1A1 in human samples, making it an excellent choice for Western blot applications.AKR1A1, also known as aldo-keto reductase family 1 member A1, plays a crucial role in the metabolism of endogenous and exogenous compounds, including detoxification of reactive aldehydes and reduction of lipid peroxidation products.
Its dysregulation has been implicated in various diseases, such as cancer, diabetic complications, and neurodegenerative disorders. Therefore, studying AKR1A1 expression and activity is essential for understanding its involvement in these pathological processes and potentially identifying novel therapeutic targets.By utilizing the AKR1A1 Polyclonal Antibody (CAB1068) in research, scientists can gain valuable insights into the functional role of AKR1A1 in health and disease, paving the way for the development of targeted interventions and treatments in the future.
Product Name:
AKR1A1 Rabbit Polyclonal Antibody
SKU:
CAB1068
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1).
apical plasma membrane, cytosol, extracellular exosome, extracellular space
Calculated MW:
37kDa
Observed MW:
37kDa
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
10327
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AKR1A1 antibody (CAB1068) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
