AKAP9 Antibody (PACO15360)
- SKU:
- PACO15360
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AKAP9 Antibody (PACO15360)
The AKAP9 Polyclonal Antibody (PAC015360) is specifically designed for researchers studying AKAP9, a key protein involved in cell signaling and coordination of cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blot applications. By targeting the AKAP9 protein, this antibody facilitates the detection and analysis of AKAP9 expression in various cell types, making it an excellent tool for investigations in cell biology and signal transduction pathways.AKAP9, also known as A Kinase Anchor Protein 9, plays a crucial role in organizing and localizing signaling molecules within the cell, thereby influencing important cellular functions such as proliferation, differentiation, and survival.
Understanding the specific functions and interactions of AKAP9 is essential for unraveling its impact on various physiological and pathological processes, including cancer development, neurological disorders, and cardiovascular diseases. By delving into the intricacies of AKAP9-mediated signaling, researchers can uncover novel therapeutic targets and strategies for treating a range of human ailments.
| Antibody Name: | AKAP9 Antibody (PACO15360) |
| Antibody SKU: | PACO15360 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human AKAP9 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15360(AKAP9 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. |
| Synonyms: | A kinase (PRKA) anchor protein (yotiao) 9 |
| UniProt Protein Function: | AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 7q21-q22Cellular Component: Golgi apparatus; centrosome; pericentriolar material; voltage-gated potassium channel complex; cytoskeleton; intracellular membrane-bound organelle; cytosolMolecular Function: protein binding; potassium channel regulator activity; protein complex scaffold; receptor bindingBiological Process: synaptic transmission; transport; organelle organization and biogenesis; spermatogenesis; mitotic cell cycle; signal transduction; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-serine phosphorylation; Sertoli cell developmentDisease: Long Qt Syndrome 11 |
| UniProt Protein Details: | |
| NCBI Summary: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q99996 |
| NCBI GenInfo Identifier: | 14194461 |
| NCBI Gene ID: | 10142 |
| NCBI Accession: | Q99996.3 |
| UniProt Secondary Accession: | Q99996,O14869, O43355, O94895, Q75N20, Q9UQH3, Q9UQQ4 Q9Y6B8, Q9Y6Y2, A4D1F0 |
| UniProt Related Accession: | Q99996 |
| Molecular Weight: | 455,423 Da |
| NCBI Full Name: | A-kinase anchor protein 9 |
| NCBI Synonym Full Names: | A kinase (PRKA) anchor protein 9 |
| NCBI Official Symbol: | AKAP9Â Â |
| NCBI Official Synonym Symbols: | LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16AÂ Â |
| NCBI Protein Information: | A-kinase anchor protein 9; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein kinase A anchoring protein 9; A kinase (PRKA) anchor protein (yotiao) 9; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein kinase N-associated protein |
| UniProt Protein Name: | A-kinase anchor protein 9 |
| UniProt Synonym Protein Names: | A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9; Protein yotiao |
| Protein Family: | A-kinase anchor protein |
| UniProt Gene Name: | AKAP9Â Â |
| UniProt Entry Name: | AKAP9_HUMAN |
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