AKAP7 Antibody (PACO24839)
- SKU:
- PACO24839
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | AKAP7 Antibody (PACO24839) |
| Antibody SKU: | PACO24839 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC,IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human A-kinase anchor protein 7 isoforms α and β protein (1-81AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO24839 at dilution of 1:100. |
 | Immunofluorescence staining of HepG2 cells with PACO24839 at 1:120,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO24839 at dilution of 1:100. |
| Background: | Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. |
| Synonyms: | A-kinase anchor protein 7 isoforms α and β (AKAP-7 isoforms α and beta) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoforms alpha/beta) (PRKA7 isoforms alpha/beta), AKAP7, AKAP15 AKAP18 |
| UniProt Protein Function: | AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytosol Molecular Function:protein binding; protein kinase A binding Biological Process: protein localization |
| NCBI Summary: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011] |
| UniProt Code: | O43687 |
| NCBI GenInfo Identifier: | 25108878 |
| NCBI Gene ID: | 9465 |
| NCBI Accession: | O43687.4 |
| UniProt Secondary Accession: | O43687,Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4, A8K2K6, |
| UniProt Related Accession: | Q9P0M2,O43687 |
| Molecular Weight: | 11kDa |
| NCBI Full Name: | A-kinase anchor protein 7 isoforms alpha and beta |
| NCBI Synonym Full Names: | A-kinase anchoring protein 7 |
| NCBI Official Symbol: | AKAP7Â Â |
| NCBI Official Synonym Symbols: | AKAP15; AKAP18Â Â |
| NCBI Protein Information: | A-kinase anchor protein 7 isoform gamma; A-kinase anchor protein 7 |
| UniProt Protein Name: | A-kinase anchor protein 7 isoforms alpha and beta |
| UniProt Synonym Protein Names: | A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta |
| Protein Family: | A-kinase anchor protein |
| UniProt Gene Name: | AKAP7Â Â |
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