Anti-AKAP7 Antibody (PACO15357)

Antibody Name:	AKAP7 Antibody (PACO15357)
Antibody SKU:	PACO15357
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50
Species Reactivity:	Human
Immunogen:	Fusion protein of human AKAP7

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15357(AKAP7 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
	Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder carcinoma tissue, Primary antibody: PACO15357(AKAP7 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15357(AKAP7 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.

Synonyms:

A kinase (PRKA) anchor protein 7

UniProt Protein Function:	AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q23.2 Cellular Component: cytosol Molecular Function:protein binding; protein kinase A binding Biological Process: protein localization
NCBI Summary:	This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]
UniProt Code:	O43687
NCBI GenInfo Identifier:	25108878
NCBI Gene ID:	9465
NCBI Accession:	O43687.4
UniProt Secondary Accession:	O43687,Q5TBR9, Q5TBS0, Q9HCZ8, Q9P0G4, A8K2K6,
UniProt Related Accession:	Q9P0M2,O43687
Molecular Weight:	11kDa
NCBI Full Name:	A-kinase anchor protein 7 isoforms alpha and beta
NCBI Synonym Full Names:	A-kinase anchoring protein 7
NCBI Official Symbol:	AKAP7
NCBI Official Synonym Symbols:	AKAP15; AKAP18
NCBI Protein Information:	A-kinase anchor protein 7 isoform gamma; A-kinase anchor protein 7
UniProt Protein Name:	A-kinase anchor protein 7 isoforms alpha and beta
UniProt Synonym Protein Names:	A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta
Protein Family:	A-kinase anchor protein
UniProt Gene Name:	AKAP7

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)