AKAP7 Antibody (PACO07668)
- SKU:
- PACO07668
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
AKAP7 Antibody (PACO07668)
The AKAP7 Polyclonal Antibody (PACO07668) is a valuable tool for researchers studying AKAP7, a protein that plays a key role in cellular signaling and stress response pathways. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot and immunofluorescence applications.AKAP7, also known as A-kinase anchor protein 7, is involved in anchoring protein kinase A (PKA) to specific subcellular locations, allowing for precise control of cellular responses to various stimuli. Its function in regulating PKA signaling makes it a promising target for investigating cellular processes like gene expression, metabolism, and cell growth.
By utilizing the AKAP7 Polyclonal Antibody, researchers can accurately detect and analyze AKAP7 expression in a variety of cell types and experimental conditions. This antibody is essential for studies exploring the role of AKAP7 in cellular signaling pathways, and its potential implications in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. Understanding the function of AKAP7 is crucial for developing targeted therapies aimed at manipulating cellular signaling for therapeutic benefit.
| Antibody Name: | AKAP7 Antibody (PACO07668) |
| Antibody SKU: | PACO07668 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human AKAP7 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | A kinase (PRKA) anchor protein 7;AKAP7;AKAP18 ; |
| UniProt Protein Function: | AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 6q23 Cellular Component: apical plasma membrane; plasma membrane; cytosol; nucleus; lateral plasma membrane Molecular Function:protein binding; protein kinase A binding; nucleotide binding; protein kinase binding Biological Process: regulation of action potential; protein localization; ion transport |
| NCBI Summary: | This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011] |
| UniProt Code: | Q9P0M2 |
| NCBI GenInfo Identifier: | 4757738 |
| NCBI Gene ID: | 9465 |
| NCBI Accession: | NP_004833.1 |
| UniProt Secondary Accession: | Q9P0M2,Q9P0M2, |
| UniProt Related Accession: | O43687,Q9P0M2 |
| Molecular Weight: | 14kDa |
| NCBI Full Name: | A-kinase anchoring protein 7 isoform alpha |
| NCBI Synonym Full Names: | A-kinase anchoring protein 7 |
| NCBI Official Symbol: | AKAP7Â Â |
| NCBI Official Synonym Symbols: | AKAP15; AKAP18Â Â |
| NCBI Protein Information: | A-kinase anchoring protein 7 |
| UniProt Protein Name: | A-kinase anchor protein 7 isoforms alpha and beta |
| UniProt Synonym Protein Names: | A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta |
| Protein Family: | A-kinase anchor protein |
| UniProt Gene Name: | AKAP7Â Â |
| UniProt Entry Name: | AKA7A_HUMAN |
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