The AKAP2 Polyclonal Antibody (PACO04361) is a valuable tool for researchers studying AKAP2, a protein involved in cellular signaling and compartmentalization. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the AKAP2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology and signal transduction research.AKAP2, also known as A-kinase anchor protein 2, is a scaffolding protein that plays a crucial role in targeting protein kinase A (PKA) to specific subcellular locations. This function is essential for the regulation of various cellular processes, including cell growth, differentiation, and gene expression.
Understanding the role of AKAP2 is important for unraveling the complexities of cellular signaling pathways and for developing targeted therapies for diseases associated with dysregulated signaling.With its high specificity and reactivity, the AKAP2 Polyclonal Antibody (PACO04361) is a valuable tool for researchers seeking to investigate the functions and mechanisms of AKAP2 in health and disease. Its versatility and reliability make it a valuable asset for studies aimed at unraveling the intricate signaling networks that govern cellular behavior.
Antibody Name:
AKAP2 Antibody
Antibody SKU:
PACO04361
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the N-terminal region of human AKAP 2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
AKAP2; KIAA0920; PRKA2; A-kinase anchor protein 2; AKAP-2; AKAP-KL; Protein kinase A-anchoring protein 2; PRKA2
UniProt Protein Function:
AKAP2: Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 9q31.3
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene binds to the regulatory subunit of protein kinase A and is found associated with the actin cytoskeleton. The encoded protein mediates signals carried by cAMP and may be involved in creating polarity in certain signaling processes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
