The AKAP17A Polyclonal Antibody (PAC021819) is a valuable tool for research involving AKAP17A, a protein involved in the regulation of intracellular signaling pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to AKAP17A, enabling its detection and analysis in a variety of cell types, making it ideal for studies in cell signaling and signal transduction research.AKAP17A, also known as A Kinase Anchor Protein 17A, plays a crucial role in anchoring protein kinase A to specific subcellular locations, thereby modulating various signaling cascades.
Its involvement in signal transduction pathways makes it a promising target for research into various cellular processes and diseases. Understanding the function of AKAP17A is essential for unraveling its impact on cellular signaling and developing potential therapeutic strategies targeting this protein.
Antibody Name:
AKAP17A Antibody (PACO21819)
Antibody SKU:
PACO21819
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human SFRS17A.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from NIH-3T3 cells, using SFRS17A antibody.
Background:
Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre-mRNA splicing in a PKA-dependent manner. Voland J.R., Proc. Natl. Acad. Sci. U.S.A. 89:10425-10429(1992).
Synonyms:
A-kinase anchor protein 17A; 721P; B-lymphocyte antigen; Protein XE7; Protein kinase A-anchoring protein 17A
UniProt Protein Function:
SFRS17A: Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:RNA splicing
Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.32
Molecular Function:protein binding; protein kinase A binding
Biological Process: regulation of RNA splicing
NCBI Summary:
This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Sep 2010]
